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Laboratory and clinical study of the biological activity of poly guanylic acid poly cytidylic acid complex



Laboratory and clinical study of the biological activity of poly guanylic acid poly cytidylic acid complex



Voprosy Virusologii (4): 466-470



Poly(G).cntdot.poly(C) inoculated i.v. to mice in a dose of 100 .mu.g induced interferon in the blood in amounts comparable to those induced by poly(I).cntdot.poly(C). In contrast to the rapid accumulation (within 2 h after induction) and rapid disappearance of interferon in response to poly(I).cntdot.poly(C), the interferon induced by poly(G).cntdot.poly(C) reached a maximum titer by 6 h and remained at a high level for 24 h after inoculation. When given to human volunteers intranasally in a dose of 6 mg, the poly(G).cntdot.poly(C) complex induced interferon in the serum in 70% of the subjects in a titer of 85 units/ml within 24 h. [Sendai virus was used as an indicator.].

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