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Laboratory confirmation of phenyl ketonuria by combined paper chromatography and inhibition assay

Laboratory confirmation of phenyl ketonuria by combined paper chromatography and inhibition assay

Paediatrie und Paedologie 17(2): 165-170

It is absolutely necessary to confirm any positive screening result for phenylketonuria by 2 or more independent procedures carried out on 2 or more different [infant] blood specimens before initiation of diet treatment. Details for a combined paper chromatography and inhibition assay of cut paper strips for positive identification of blood phenylalanine are given. This procedure correlates the partition between 2 solvents, the reaction to ninhydrin and the reaction in inhibition assay.

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Accession: 005787577

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PMID: 7099675

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