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Laboratory evaluation of anti fungal agents a comparative study of 5 imidazole derivatives of clinical importance

Laboratory evaluation of anti fungal agents a comparative study of 5 imidazole derivatives of clinical importance

Journal of Antimicrobial Chemotherapy 6(6): 749-762

Minimal inhibitory concentrations [MIC] of clotrimazole, econazole, ketoconazole, miconazole and tioconazole for pathogenic yeasts, aspergilli, dermatophytes and other filamentous fungi were determined under a variety of experimental conditions with inocula standardized by ATP photometry. MICs were measured with liquid and solid media, media with and without added serum, media with and without peptone, and for different concentrations of fungal inocula. Although the effects of these test variables on MIC was usually similar for all imidazoles and fungi tested, the extent of the effects was often conspicuously different for a particular imidazole or a particular fungal type. It was concluded that the concpet that imidazole antifungals act similarly on all types of fungi should be applied with caution. Specific observations included the demonstration that aspergillus hyphae and conidia were equally susceptible to all 5 imidazoles and that the solubilities of the compounds in physiological saline ranged from 5-80 mg/l.

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