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Laboratory evaluation of pirbenicillin a new penicillin with anti pseudomonal activity



Laboratory evaluation of pirbenicillin a new penicillin with anti pseudomonal activity



Journal of Antimicrobial Chemotherapy 3(2): 185-189



The new penicillin, pirbenicillin, was 8-16 times more active than carbenicillin against many strains of Pseudomonas aeruginosa, but was uniformly less active against indole-positive Proteus spp. The intrinsic activity of the new antibiotic against ampicillin-sensitive Escherichia coli was intermediate between those of ampicillin and carbenicillin. No unusual activity of pirbenicillin was detected among a group of enterobacteria previously shown to exhibit distinct patterns of resistance to .beta.-lactam antibiotics.

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Accession: 005787810

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PMID: 405364


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