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Laboratory investigations of the damage induced by chronic alcoholism

Laboratory investigations of the damage induced by chronic alcoholism

Giornale Italiano di Chimica Clinica 11(2): 101-106

Chronic alcoholism may induce hepatic injury and alterations of haemostasis-involved proteins. The Authors made a multiparametric research of haemostatic function (bleeding time, platelets aggregation, Quick's time, aPTT, Normotest, Fibrinogenaemia. TEG, lysis time, plasminogen, paracoagulation tests) in 20 subjects with chronic alcoholism, without any evidence of hepatocellular damage, but with a bioptically verified hepatic steatosis and an increase of gamma-GT and MCV values. The same multiparametric research was repeated in 6 subjects after some months of abstinence (3-12). Results show that hyperfibrinogenaemia and decrease of fibrinolytic activity are often present in chronic alcoholics: they are reversible to normal values, after abstinence, as it is shown by the results obtained in 6 subjects. The results indicate that a multiparametric research (fibrinogenaemia, fibrinolytic activity, gamma-GT and MCV) can show a possible chronic alcoholism damage and its evolution.

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