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Lack of mutagenicity of some phyto estrogens in the salmonella typhimurium mammalian microsome assay



Lack of mutagenicity of some phyto estrogens in the salmonella typhimurium mammalian microsome assay



Mutation Research 78(4): 317-322



Phytoestrogens were tested for mutagenicity using a variation of the Salmonella typhimurium/mammalian [rat liver] microsome (or Ames) assay. Zearalenone is a mycotoxin produced by a grain contaminant, Fusarium graminearum (Gibberella zeae) and the isomers of zearalanol are reduced derivatives of this compound. The remaining compounds are all flavonoids which occur naturally at relatively high concentrations in many plants, particularly legumes. Daidzein, genistein, formononetin and biochanin-a are isoflavones and coumestrol is a coumestan. Each compound was tested at several concentrations ranging 1-500 .mu.g per plate. The microsomal fraction was obtained from Aroclor 1254-induced rat livers. None of the compounds tested was mutagenic to S. typhimurium strains TA 1538, TA 98 or TA 100 at any concentration. [Naturally-occuring estrogenic substances have been identified in human foods as normal plant components and as contaminating mycotoxins.].

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