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Latentiation of chemo therapeutical agents preparation of saccharide polymers of schistosomicidal and anti malarial agents



Latentiation of chemo therapeutical agents preparation of saccharide polymers of schistosomicidal and anti malarial agents



Revista de Farmacia e Bioquimica da Universidade de Sao Paulo 17(1): 28-46



In an attempt to obtain long-acting and less toxic drugs, saccharidic polymers of schistosomicides (amphotalide and pararosaniline) and antimalarial agents (dapsone, pyrimethamine, trimethoprim and sulfadimethoxime) were prepared. These prodrugs were obtained by reacting starch chloroformate with these active agents at room temperature and at 60.degree. C. Dapsone derivative prepared at 60.degree. C (CFA-lt) and pyrimethamine derivative prepared at room temperature (CFA-3) were active against experimental malaria and schistosomiasis, respectively.

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