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Lebers optic neuropathy 2. fluorescein angiographic studies

Lebers optic neuropathy 2. fluorescein angiographic studies

Documenta Ophthalmologica 53(2): 113-122

Fluorescein angiography was performed in 71 persons at risk to develop Leber's Optic Neuropathy (LON), in 10 female carriers of this disease and in 5 patients during the acute phase. The examination was performed in 3 university eye clinics. The angiograms were randomly mixed with an equal number of controls and reviewed in a blind fashion on 2 occasions by 2 observers. A scoring system was developed on the basis of the peripapillary microvascular changes known to occur in the acute phase of LON. All 5 patients could be recognized in this manner. In the pictures of one of the clinics, which were of good quality, a significant difference in scoring between the at risk and control groups appeared to exist. Carriers also may have the same fluorescein angiographic abnormalities. One man from the at risk group who obtained high abnormal scores, identical to patients in the acute phase, developed LON 6 mo. later.

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Accession: 005800134

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PMID: 7173013

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