Leukemia in workers exposed to ethylene oxide

Hogstedt, C.; Malmqvist, N.; Wadman, B.

JAMA 241(11): 1132-1133


ISSN/ISBN: 0098-7484
PMID: 105157
DOI: 10.1001/jama.1979.03290370036024
Accession: 005804519

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Ethylene oxide, a gaseous sterilant extensively used within health care facilities, is known to be a mutagen in bacteria and in human lymphocytes. The Environmental Protection Agency as well as the National Institue of Occupational Safety and Health have recently stipulated certain conditions for the use of ethylene oxide despite the lack of case reports or epidemiologic studies concerning carcinogenicity. We report three cases of leukemia that occurred between 1972 and 1977 in a relatively small group of Swedish workers exposed to ethylene oxide. According to national statistics, 0.2 cases of leukemia would have been expected. The time-weighted average ethylene oxide concentration was 20+/-10 ppm.

Leukemia in workers exposed to ethylene oxide