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Levels of plasma proteins in human and rat fetal cerebro spinal fluid and the development of the blood cerebro spinal fluid barrier



Levels of plasma proteins in human and rat fetal cerebro spinal fluid and the development of the blood cerebro spinal fluid barrier



Neuropaediatrie 8(4): 345-353



High levels of albumin, .alpha.-fetoprotein (AFP), Ig[immunoglobulin]G, prealbumin and transferrin were detected in CSF of human fetuses between 14-25 wk old. The concentration of each plasma protein in CSF varied during the gestational period in relation to its serum levels and rate of synthesis and as a consequence of a reduced permeability of the blood-CSF barrier after 22 wk. The higher CSF levels of AFP were detected in fetuses about 16 wk old, while the highest values of albumin were observed in CSF from fetuses between 20-24 wk old. Experimental work also showed that in rats the permeability of the blood-CSF barrier was incomplete during fetal and perinatal life. When 125I-labeled albumin and IgG or 14C-estrogen and testosterone were injected i.p. in newborn rats, the labeled proteins and hormones were detected in fetal blood and CSF 4 h after the injection. These results were discussed in view of the suggestion that maternal abnormal states with regard to hormones and antibrain antibodies may affect the development of the nervous system and unfolding of behavior.

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