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Lifetime exposure to 2.4 parts per million nitric oxide in mice



Lifetime exposure to 2.4 parts per million nitric oxide in mice



Environmental Research 22(1): 254-263



JCL:ICR mice were exposed to 2.4 ppm NO during their life span, while contaminated NO2 was kept below 0.04 ppm. Body weight and survival rate which were observed up to 29 mo. did not show any difference between the control and exposed mice except for the decreased survival rate of 16-mo. exposure mice. The deceased mice had leukemia, lymphoma, nephritis and lung adenoma, which appeared to spontaneously occur with no significant difference in their incidence between the groups. Some mice were sacrificed 3, 6, 13 and 23 mo. after the start of exposure and examined by various hematological, biochemical and histological methods. The level of nitrosyl-hemoglobin of the exposed mice detected by the ESR method was only 0.01% and methemoglobin did not increase. The change of osmotic resistance of the red blood cells and the decrease of serum haptoglobin suggested acceleration of hemolysis, though at a minimum level. Because there was no difference in the histological findings of the lungs between the control and exposed mice, the effect of NO seemed to be milder than that of NO2 with respect to the effect on the respiratory organs.

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