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Link protein and a hyaluronic acid binding region as components of aorta proteo glycan



Link protein and a hyaluronic acid binding region as components of aorta proteo glycan



Biochemical & Biophysical Research Communications 95(4): 1823-1831



Proteoglycans from bovine aorta were extracted with 4 M guanidine HCl in the presence of protease inhibitors and fractionated by density gradient centrifugation in CsCl. The bottom fraction from a dissociative gradient contained proteoglycans with a size distribution similar to that of cartilage proteoglycans. Antigens were present which reacted with antisera raised against the hyaluronic acid-binding region and chondroitin sulfate peptides from cartilage proteoglycans. By associative and dissociative density gradient centrifugations, a fraction was obtained which was precipitated by antiserum to link proteins of bovine nasal cartilage and had the same electrophoretic mobility as link protein 1.

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Accession: 005813495

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PMID: 7417346


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