Localization of the human fibronectin (FN) gene on chromosome 8 by a specific enzyme immunoassay

Rennard, S.I.; Church, R.L.; Rohrbach, D.H.; Shupp, D.E.; Abe, S.; Hewitt, A.T.; Murray, J.C.; Martin, G.R.

Biochemical Genetics 19(5-6): 551-566

1981


ISSN/ISBN: 0006-2928
PMID: 6794562
DOI: 10.1007/bf00484626
Accession: 005824769

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Abstract
The fibronectin produced by clonal murine-human hybrid cell lines containing various complements of human chromosomes was measured. Human and murine fibronectins were assayed by specific immunoassay, and the production of human fibronectin was correlated with karyology and isozyme markers for specific human chromosomes. A 100% concordance between the expression of human fibronectin and glutathione reductase, a marker for human chromosome 8, is shown, indicating that chromosome 8 codes for the fibronectin polypeptide.

Localization of the human fibronectin (FN) gene on chromosome 8 by a specific enzyme immunoassay