Long-lasting depletion of spinal cord 5-hydroxytryptamine or catecholamines after intraspinal injection of 5,7-dihydroxytryptamine or 6-hydroxydopamine to newborn rats

Carruba, M.O.; Keller, H.H.; Da Prada, M.

Neuroscience Letters 35(2): 173-178


ISSN/ISBN: 0304-3940
PMID: 6190112
DOI: 10.1016/0304-3940(83)90546-3
Accession: 005827212

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Intraspinal (i.s.) injection of 5,7-dihydroxytryptamine (5,7-DHT) to newborn rats resulted in a longlasting and rather selective lesion of the 5-hydroxytryptamine (5-HT) neurons in the spinal cord, leaving the 5-HT systrem in the brain unaltered, as judged by the marked reduction of spinal but not of cerebral 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) and by the lack of effect on the noradrenaline [norepinephrine (NA)] and dopamine levels in both CNS structures 30 and 70 days after 5,7-DHT treatment. After i.s. injection of 6-hydroxydopamine at birth, the only change in the 3 monoamines in spinal cord and brain, 105 days after treatment, was a marked decrease of NA in the spinal cord. Intracerebroventricular (i.c.v.) injection of 5,7-DHT at birth led to a pronounced depletion of 5-HT and 5-HIAA in both brain and spinal cord 30 and 70 days later, reflecting degeneration of both ascending and descending 5-HT pathways. Thus, i.s. injection of neurotoxins to newborn rats may be useful in studying the role of the monoaminergic system of the spinal cord.