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Long term intra nasal lhrh agonist treatment for contraception in women



Long term intra nasal lhrh agonist treatment for contraception in women



Fertility & Sterility 38(2): 190-193



Fifty-one female volunteers used a superactive stimulatory LHRH analog for suppression of ovulation for 3-12 mo. The potent LHRH agonist D-Ser(TBU)6-EA10-LHRH was administered intranasally once daily in a dose of 400-600 .mu.g. No pregnancies occurred during the 283 treatment months. Severe bleeding disturbances were not observed during the long-term treatment. No signs of hyperplastic changes were found in endometrial biopsies. There were no serious side effects. Ovulation promptly returned after cessation of treatment even in women with amenorrhea during treatment periods of 1 yr or more. Thus, long-term LHRH agonist treatment proved to be a safe, effective, and rapidly reversible new method for peptide contraception.

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Accession: 005829363

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