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Lymphocyte mediated cyto toxicity against tumor cells part 3 differentiation of concanavalin a activated cyto toxic effector cells



Lymphocyte mediated cyto toxicity against tumor cells part 3 differentiation of concanavalin a activated cyto toxic effector cells



European Journal of Immunology 6(5): 317-320



The maturation of selected T [thymus-derived] cell responses in the lymphoid organs of irradiated CBA mice was followed after adoptive transfer of syngeneic fetal liver cells. Mitogenic responsiveness to phytohemagglutinin (PHA) and concanavalin A (Con A) reached control values 3 wk after reconstitution in the thymus, spleen and lymph node of fetal liver repopulated animals. Spleen and lymph node cell reactivity in mixed lymphocyte culture reactions required 6 wk to reach significant values. The ability of spleen cell suspensions to be activated by Con A into cytotoxic effector lymphocytes appeared after only 2-3 wk. Two functionally distinct T [thymus-derived] cell subpopulations exist in the spleen, 1 which can be activated into cytotoxic effector lymphocytes by Con A, and 1 which responds to alloantigens by DNA synthesis.

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Accession: 005838572

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