Maintenance of brain glycogen stores in young rats subjected to progressive starvation and perturbed pattern of feeding correlation with adrenal catecholamines

Bastart Malsot, M.; Ismahan Okyayuz, G.; Parvez, H.; Parvez, S.

Biogenic Amines 3(1): 73-83


ISSN/ISBN: 0168-8561
Accession: 005844912

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The influence of progressive starvation, undernutrition and perturbed alimentary rhythms upon cerebral glycogen was studied in 2 groups of developing rats weighing 50 and 90 g. Starvation of 48 and 60 h resulted in marked decreases of brain glycogen stores of 50 as well as 90-g rats. After 60 h of starvation the content of brain protein was increased. When the 50 g rats starved for 60 h were fed ad libitum for the next 24 h an increase in brain glycogen content took place whereas a similar treatment to 90 g rats provoked a further decrease in cerebral glycogen. Perturbed pattern of feeding (24 h starvation + 8 h food for 3 weeks) resulted in 90% decrease of brain glycogen when the rats were killed after the last starvation and this decrease was restored to normal value when the rats were re-fed for 8 h before death. Another pattern of feeding (16 h starvation + 8 h food for 3 weeks) did not show any marked effect on cerebral glycogen content if the rats were killed after the last starvation but a significant decrease took place if the animals were killed 8 h after last feeding. Undernutrition (5 g/day for 3 weeks) produced 64% decrease in brain glycogen and 40% decrease in brain protein. Peripheral glucose in the circulation also showed progressive decreases up to 45% in 90-g rats and 60% in the 50-g rats after 60 h of starvation. Refeeding during 24 h to 60 h starved rats restored glycemia to a great extent (94% of control in 50-g rats and 77% in 90-g rats). Perturbed pattern of feeding for 3 weeks as well as undernutrition decreased blood glucose markedly up to 50% and 65% of controls respectively. Correlations between adrenal catecholamines and glycogen metabolism in central and peripheral regions were also made to have some evaluation of a possible index of transmitter modulated changes in carbohydrate regulation.