Male and female mice living in differently sized groups part 1 noradrenaline metabolism in discrete brain areas open field activity and corticoid release

Frank, K.; Raab, A.

Journal of Comparative Physiology A Sensory Neural and Behavioral Physiology 99(2): 153-164


Accession: 005846360

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The influence of crowding in different group sizes on the metabolism of noradrenaline (NE) in 6 different brain areas and on some peripheral data in male and female mice was investigated. In the basal ganglia, the diencephalon and the mesencephalon-pons region, the NE turnover decreases from animals housed singly to groups of 16 animals per cage and then increases again. In the cortex and in the cerebellum no changes of the NE metabolism with group size took place. Of all parameters investigated, only the corticoid levels in the plasma after exposure to a new environment correlated individually with the density-induced changes of the NE metabolism in the basal ganglia. The effects of acute and chronic stress on the NE metabolism and on amphetamine toxicity were discussed.