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Mass chemo therapy with spaced doses of di ethyl carbamazine effects in tahiti on microfilaremia due to wuchereria bancrofti var pacifica



Mass chemo therapy with spaced doses of di ethyl carbamazine effects in tahiti on microfilaremia due to wuchereria bancrofti var pacifica



Bulletin of the World Health Organization 58(5): 779-784



Mass campaigns against lymphatic filariasis employing diethylcarbamazine (DEC) are usually limited in time by the magnitude and cost of the programs advocated. The results given by a chemotherapy program using DEC administered by the spaced dose method (1 dose of DEC/yr) are discussed. This program, which was applied for 4 yr to a Polynesian population numbering 50,000, made it possible to maintain prolonged and continuous pressure on the microfilarial population. The program resulted in reductions in the proportion of carriers from 4.4% to 1.9% and in reducing the average level of microfilaremia in carriers from 21.2 to 11.7 mf/20 mm3 of blood and in the total population studied from 0.9-0.2 mf/20 mm3. Because of practical difficulties in application, the population received, on the average, only 2.76 doses of DEC/person spread over 4 yr. The method used is applicable and effective in the field. Its main advantages are simplicity and low cost, making it suitable for long-term use by basic health services. The effects observed give the hope of a gradual advance towards eradication.

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Accession: 005854410

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PMID: 7028300


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