+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 2. effects of administration of ammonia on blood branched chain amino acid concentrations in rats



Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 2. effects of administration of ammonia on blood branched chain amino acid concentrations in rats



Acta Scholae Medicinalis Universitatis in Gifu 29(4): 630-641



Effects of i.v. administration of ammonia on the levels of blood amino acids, plasma [immunoreactive] insulin (IRI), plasma [immunoreactive] glucagon (IRG) and plasma glucose were studied in rats. In ammonia-administered rats whose plasma ammonia levels were elevated to 414.2 .mu.g/dl, the levels of blood branched chain amino acid, such as valine, isoleucine and leucine were reduced to .apprx. 70% as compared with those in control rats. Blood branched chain amino acid levels were reduced as the function of plasma ammonia levels. As compared with control rats, the blood glucose levels were significantly elevated in ammonia-administered rats, whereas no changes in plasma IRI and IRG were observed by ammonia administration. Hyperammonemia apparently induces the reduction in blood branched chain amino acid levels without association of the changes of plasma IRI and IRG levels. Hyperammonemias may be one of the crucial factors for decreases in blood branched chain amino acid levels in liver cirrhosis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005867073

Download citation: RISBibTeXText


Related references

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 3. effects of administration of short chain fatty acid on blood branched chain amino acid concentrations in rats. Acta Scholae Medicinalis Universitatis in Gifu 29(4): 642-651, 1981

Comparative study of amino acid, ammonia and pancreatic hormone levels in the blood of cirrhotic patients following intragastric and intravenous administration of a branched-chain amino acid-enriched solution. Acta Medica Okayama 37(5): 441-445, 1983

Lowering effect of branched chain amino acid and arginine on blood ammonia level in patients with liver cirrhosis. Gastroenterology 108(4 Suppl. ): A1105, 1995

Divergent Induction of Branched-Chain Aminotransferases and Phosphorylation of Branched Chain Keto-Acid Dehydrogenase Is a Potential Mechanism Coupling Branched-Chain Keto-Acid-Mediated-Astrocyte Activation to Branched-Chain Amino Acid Depletion-Mediated Cognitive Deficit after Traumatic Brain Injury. Journal of Neurotrauma 35(20): 2482-2494, 2018

Interactions among the branched-chain amino acids and their effects on methionine utilization in growing pigs: effects on plasma amino- and keto-acid concentrations and branched-chain keto-acid dehydrogenase activity. British Journal of Nutrition 83(1): 49-58, 2000

The effects of plasma insulin and branched chain amino acid concentrations on blood brain barrier amino acid transport following porta caval shunt. Gastroenterology 75(5): 969, 1978

Beneficial effects of branched-chain amino acids on altered protein and amino acid metabolism in liver cirrhosis: evaluation in a model of liver cirrhosis induced in rats with carbon tetrachloride. Hepatology Research 27(2): 117-123, 2003

Impact of Branched-Chain Amino Acid Granule Therapy in Patients with Hepatocellular Carcinoma Who Have Normal Albumin Levels and Low Branched-Chain Amino Acid to Tyrosine Ratios. Nutrition and Cancer 71(7): 1132-1141, 2019

Effect of branched-chain amino acid granules on 99mTc-GSA liver scintigraphy and branched-chain amino acid tyrosine mole ratio in cirrhotic patients. Gastroenterology 118(4 Suppl 2 Part 2): AASLD A148, 2000

Effects of branched-chain-enriched amino acid solution on insulin and glucagon secretion and blood glucose level in liver cirrhosis. Scandinavian Journal of Gastroenterology 33(8): 853-859, 1998

Differential effects of insulin-induced hypoglycaemia on the plasma branched-chain and non-branched-chain amino acid concentrations in humans. Diabete & Metabolisme 18(4): 277-282, 1992

A comparison of the effects of intravenous infusion of individual branched-chain amino acids on blood amino acid levels in man. Clinical Science 60(1): 95-100, 1981

Intracellular and extracellular amino acid concentrations in ammonium infused rats evidence that hyperammonemia reduces branched chain amino acid levels. Kleinberger, G , P Ferenci, P Riederer And H Thaler (Ed ) Advances in Hepatic Encephalopathy And Urea Cycle Diseases 5th International Symposium on Ammonia, Semmering, Austria, May 16-19, Xii+769p S Karger: Basel, Switzerland; New York, N Y , Usa Illus 552-554, 1984

Branched-chain amino acid supplementation in treatment of liver cirrhosis: Updated views on how to attenuate their harmful effects on cataplerosis and ammonia formation. Nutrition 41: 80-85, 2017

Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats. Metabolism: Clinical and Experimental 64(9): 1157-1164, 2015