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Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 3. effects of administration of short chain fatty acid on blood branched chain amino acid concentrations in rats



Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 3. effects of administration of short chain fatty acid on blood branched chain amino acid concentrations in rats



Acta Scholae Medicinalis Universitatis in Gifu 29(4): 642-651



Effects of i.v. administration of caproic acid and butyric acid on the levels of blood amino acids, plasma [immunoreactive] insulin (IRI), plasma [immunoreactive] glucagon (IRG) and plasma glucose were studied in rats. In caproic acid and butyric acid administered rats, whose plasma caproic acid and butyric acid levels were elevated to 1.55 .mu.g/ml and 1.84 .mu.g/ml, respectively, the levels of blood branched chain amino acid, such as valine, isoleucine and leucine were reduced to .apprx. 70% as compared with those in control rats, whose plasma caproic acid and butyric acid levels were 0.10 .mu.g/ml and 0.91 .mu.g/ml, respectively. Blood branched chain amino acid levels were reduced as the function of plasma caproic acid levels. A synergetic effect on reduction in blood branched chain amino acid levels was observed by the simultaneous administration of caproic acid and ammonia. No significant changes were observed in plasma IRI, IRG and glucose levels by caproic acid administration. A new insight into the potential mechanisms of clinical improvements of hepatic encephalopathy by the administration of branched chain amino acid, is provided.

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