Mechanism of the enhancement of the effect of anti tumor drugs by hydrazine sulfate

Tret'yakov, A.V.; Filov, V.A.

Voprosy Onkologii (Stsburg). 23(5): 94-98


ISSN/ISBN: 0507-3758
Accession: 005869074

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The results of the in vivo and in vitro experiments using rats, mice and rabbits indicated that hydrazine sulfate is a new potent inhibitor of the biotransformation of physiologically active compounds, including those with an antitumor effect. Hydrazine sulfate apparently renders an inhibitory effect by retarding the access of xenobiotics to microsomal enzymes active centers metabolizing them. The retardation of antitumor compounds biotrnasformation effected by hydrazine sulfate in vitro enabled the explanation of the enhanced effect of cytostatics, used in combination with hydrazine sulfate in vivo. The perspective clinical application of hydrazine sulfate is apparently favorable for the potentiation of the antitumor effect of cytostatics.