Mediterraneols a novel biologically active class of rearranged diterpenoid metabolites from cystoseira mediterranea phaeophyta
Francisco, C.; Banaigs, B.; Teste, J.; Cave, A.
Journal of Organic Chemistry 51(7): 1115-1120
ISSN/ISBN: 0022-3263 Accession: 005873064
Isolation and structure of mediterraneols A, B, C, and D, a novel class of rearranged diterpenoids of mixed biogenesis, are reported from the brown alga C. mediterranea. These compounds inhibit mitotic cell division (ED50 = 2 .mu.g/mL) and present an in vivo activity during P388 tests (T/C = 128%). The structures of these metabolites were determined by chemical and spectral methods including 1H-13C 2-D shift correlation. The relative stereochemistry was obtained by NOE difference spectroscopy.