+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Metabolic fate of chromium compounds 1. comparative behavior of chromium in rat administered with chromium 51 labeled sodium chromate and chromium 51 labeled chromium chloride

Metabolic fate of chromium compounds 1. comparative behavior of chromium in rat administered with chromium 51 labeled sodium chromate and chromium 51 labeled chromium chloride

Journal of Pharmacobio Dynamics 3(1): 17-23

Comparative metabolic fate of labeled CrCl3 and NaCrO4 and interaction of these compounds in the rat liver and blood were investigated after their oral and i.v. administration. Gastrointestinal absorption of both compounds was below 1% of the oral dose, but trivalent Cr showed higher radioactivity than the hexavalent form in rats (biological half-life: CrCl3 91.79 days, Na2CrO4 22.24 days). The higher residual activity of the trivalent Cr was observed after i.v. administration. Both forms of Cr were excreted more in the urine via the kidney than in the intestinal tract after i.v. administration. When 51CrCl3 and Na2 51CrO4 were injected into rats, in the time distribution patterns of 51Cr in the organs, a significant difference was shown between oxidation states of the 2 compounds, especially in subcellular fractions of the liver and blood constituents. This significant difference mainly observed in the rat blood came from the fact that trivalent Cr possessed a high binding activity for transferrin in plasma, while hexavalent Cr was permeable into red cells and bound with Hb. CrCl3 is less toxic than NaCrO4 in animals.

(PDF emailed within 1 workday: $29.90)

Accession: 005881113

Download citation: RISBibTeXText

Related references

Study of the fecal elimination in normal rats of 3 orally administered compounds of chromium-51: sodium chromate, chromic chloride and chromium-labeled erythrocytes. Revue Francaise d'Etudes Cliniques et Biologiques 12(4): 375-379, 1967

Forms of chromium in rat blood treated in vivo and in vitro with chromium 51 sodium chromate and chromium 51 chromium ii chloride. Eisei Kagaku 32(2): 123-127, 1986

Metabolic fate of chromium compounds. I. Comparative behavior of chromium in rat administered with Na251CrO4 and 51CrCl3. Journal of Pharmacobio-Dynamics 3(1): 17-23, 1980

Absorption and excretion of chromium from orally administered chromium chloride, chromium acetate and chromium oxide in rats. Trace Elements & Electrolytes 20(1): 23-28, 2003

Distribution in mice of chromium 51 after intra venous injection of chromium 51 labeled chromium chloride. Federation Proceedings: Abstract 6230, 1982

Comparative retention/absorption of chromium from chromium chloride , chromium nicotinate , and chromium picolinate in a rat model. Journal of the American College of Nutrition 11(5): 612, 1992

Determination of chromium(III), chromium(VI) and total chromium in chromate and trivalent chromium conversion coatings by electrospray ionization mass spectrometry. Talanta 88: 533-536, 2012

Preparation of sodium chromate chromium 51 and chromic chloride chromium 51 for medical applications. International Journal of Applied Radiation & Isotopes 24(10): 599-603, 1973

Thermal stability of organo-chromium or chromium organic complexes and vapor pressure measurements on tris(2,4-pentanedionato)chromium(III) and hexacarbonyl chromium(0) by TG-based transpiration method. Chemical Engineering Science 57(17): 3603-3610, 2002

In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium(V), chromium-DNA binding and 8-hydroxy-2'-deoxyguanosine in liver and kidney of osteogenic disorder shionogi rats following treatment with chromium(VI). Carcinogenesis 20(7): 1267-1275, 1999

A comparison of chromium sesqui oxide and chromium 51 labeled chromic chloride as inert markers in calcium balance studies. Clinical Science 57(1): 89-92, 1979

Breast milk chromium and its association with chromium intake, chromium excretion, and serum chromium. American Journal of Clinical Nutrition 57(4): 519-523, 1993

Fate of tannery chromium contamination in a stream; temporal and spatial evolution of chromium (III) and chromium (VI). Journal de Physique IV, 2003

Tissue accumulation and urinary excretion of chromium in rats fed diets containing graded levels of chromium chloride or chromium picolinate. Journal of Toxicological Sciences 35(4): 485-491, 2011

Chromium nanoparticle exhibits higher absorption efficiency than chromium picolinate and chromium chloride in Caco-2 cell monolayers. Journal of Animal Physiology and Animal Nutrition 92(2): 131-140, 2008