Metabolites of the pathogenic fungus verticillium dahliae 9. mutant penta ketides and their role in melanin biosynthesis

Ten, L.N.; Stepanichenko, N.N.; Shevtsova, V.M.; Mukhamedzhanov, S.Z.; Kas'yanenko, A.G.; Otroshchenko, O.S.

Khimiya Prirodnykh Soedinenii 1980(3): 393-397


ISSN/ISBN: 0023-1150
Accession: 005885963

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Scytalone, flaviolin, 4-hydroxyscytalone and 2-hydroxyjuglone were extracted and identified from V. dahliae mutants that have various genetic blocks; 3,4,8-trihydroxytetralone and 4,8-dihydroxytetralone were observed. New experimental evidence for the participation of 1,3,6,8-tetrahydroxynaphthalene in the main pathway of melanin biosynthesis was obtained. Utilization of V. dahliae mutants with various genetic blocks in melanin biosynthesis makes it possible to analyse the process of synthesis into elementary components and to create a convenient model for the study of the mechanism of genetic regulation of the pathways of biopolymer synthesis in eukaryotes. Agents that block melanin synthesis and decrease the viability of microsclerotia in soil were obtained.