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Metal binding in chelation therapy x ray crystal structure of a copper i copper ii complex of d penicillamine



Metal binding in chelation therapy x ray crystal structure of a copper i copper ii complex of d penicillamine



Journal of the Chemical Society Chemical Communications (9): 312-313



[The structure of the intensely purple complex formed by Cu and D-penicillamine is of interest in relation to the use of the ligand in the treatment of Wilson's disease (hepatolenticular degeneration).] The purple complex formed by Cu with D-penicillamine at physiological pH is a [CuI8CuII6IIL12Cl]5- cluster [L = -S-C(Me2)-CH(NH2)CO2-] in which the 8 S3-co-ordinated CuI atoms surround a central chloride ion; each of the 6 CuII atoms is N2S2-co-ordinated by 2 chelating L ligands whose carboxy-groups are on the cluster surface.

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Accession: 005886163

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DOI: 10.1039/c39760000312


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