Mezlocillin concentrations in human aqueous humour after intravenous and subconjunctival administration
Behrens-Baumann, W.; Ansorg, R.
Chemotherapy 31(3): 169-172
ISSN/ISBN: 0009-3157 PMID: 3996085 DOI: 10.1159/000238331
Patients (27) received either 4 g i.v. infusion 1-3 h or 100 mg subconjunctival aplication of mezlocillin [an antibacterial drug] 1-12 h before cataract extraction. After i.v. administration the mean aqueous humor concentration of mezlocillin was 2.9 .mu.g/ml after 2 h. The subconjunctival dose produced a mean aqueous humor concentration of 23 and 2.6 .mu.g/ml after 3 and 12 h, respectively. These levels are above the mininum inhibitory concentration of mezlocillin for sensitive organisms.