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Mitogenic activity of adjuvant active n acetylmuramyl l alanyl d iso glutamine and its analogs



Mitogenic activity of adjuvant active n acetylmuramyl l alanyl d iso glutamine and its analogs



Biken Journal 20(2): 81-86



A synthetic cell wall peptidoglycan subunit, N-acetylmuramyl-L-alanyl-D-isoglutamine and its analogues were tested for their mitogenic effect on splenic lymphocytes from mice and guinea pigs, to elucidate the minimum chemical structure essential to the mitogenic or blastogenic activity of bacterial cell wall peptidoglycan. The minimum structure required for the mitogenic activity of bacterial cell wall peptidoglycans is probably a part of the peptidoglycan subunit monomer, N-acetylmuramyl-L-alanyl-D-isoglutamine (or -D-glutamic acid). A repetitive structure of the monomers apparently enhances the mitogenicity of the monomer.

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Accession: 005906111

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