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Mitogenic response to epidermal growth factor relationship to number affinity and down regulation of epidermal growth factor receptors in 3 murine embryo cell lines



Mitogenic response to epidermal growth factor relationship to number affinity and down regulation of epidermal growth factor receptors in 3 murine embryo cell lines



Journal of Supramolecular Structure 9(1): 41-46



Swiss 3T3 and C3H-M2 cells have a greater mitogenic response to epidermal growth factor (EGF) than do C3H-10T1/2 cells. The latter cell line has a number of EGF receptors per cell intermediate between the 2 cell lines that have a more vigorous response to EGF. Scatchard analysis of binding data indicate that all 3 cell lines have 1 class of EGF receptor, with indistinguishable affinity for the ligand. When exposed to 10-nM EGF all 3 cell lines down-regulate their EGF receptors with the same time course and to the same percentage of initial receptors.

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Accession: 005906253

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