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Mode of death and post mortem time effects on 3 3' 5 triiodothyronine levels relevance to elevated post mortem triiodothyronine levels in sudden infant death syndrome

Mode of death and post mortem time effects on 3 3' 5 triiodothyronine levels relevance to elevated post mortem triiodothyronine levels in sudden infant death syndrome

Life Sciences 35(22): 2219-2226

Post-mortem T3 [triiodothyronine] levels were reported to be increased in victims of SIDS [sudden infant death syndrome]. Recent animal studies suggest, however, that elevated T3 in SIDS may be a non-specific post-mortem phenomenon. Therefore, the possible effects of post-mortem time on T3 levels were studied in 10- and 20-day-old rats killed by various methods including sodium pentobarbital overdose, injection of KCl, cervical dislocation or asphyxia with 100% N, 95% CO2 or 100% CO2. In both age groups T3 remained unchanged or increased slightly when the animals were killed with sodium pentobarbital or KCl. Greater increases were observed when rats were killed by cervical dislocation or asphyxia (100% N, 95% N-5% CO2 or 100% CO2). T3 levels did not become elevated in asphyxiated adult rats in which the inferior vena cava was ligated immediately following death.

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Accession: 005908381

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