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Chapter 5,914

Modular arrangement of functional domains along the sequence of an aminoacyl transfer rna synthetase

Jasin, M.; Regan, L.; Schimmel, P.

Nature (London) 306(5942): 441-447

1983

ISSN/ISBN: 0028-0836
Accession: 005913883
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Gene deletions show that much of Escherichia coli alanine tRNA synthetase is dispensable for each of 3 activities and that these activities appear to require specific domains arranged linearly along the polypeptide. Thus, variable fusions of extra polypeptide domains to a catalytic core may account for the diverse sizes of aminoacyl tRNA synthetases.

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Related References

Jasin, M.; Regan, L.; Schimmel, P. 1983: Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase Nature 306(5942): 441-447
Schimmel, P.; Jasin, M.; Regan, L. 1983: Gene deletions demonstrate a mosaic of functional domains for an aminoacyl transfer rna synthetase Federation Proceedings 42(7): ABSTRACT 252
Hountondji, C.; Schmitter J M.; Fukui, T.; Tagaya, M.; Blanquet, S. 1990: Affinity labeling of aminoacyl transfer rna synthetases with adenosine triphosphopyridoxal probing the lys met ser lys ser signature sequence as the atp binding site in escherichia coli methionyl transfer rna synthetase and valyl transfer rna synthetase Biochemistry 29(5): 11266-11273
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Englisch, U.; Englisch, S.; Markmeyer, P.; Schischkoff, J.; Sternbach, H.; Kratzin, H.; Cramer, F. 1987: Structure of the yeast isoleucyl transfer rna synthetase gene ils 1 dna sequence amino acid sequence of proteolytic peptides of the enzyme and comparison of the structure to those of other known aminoacyl transfer rna synthetases Biological Chemistry Hoppe-Seyler 368(8): 971-980
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Mirande, M. 1991: Aminoacyl transfer rna synthetase family from prokaryotes and eukaryotes structural domains and their implications Cohn, W E And K Moldave (Ed ) Progress in Nucleic Acid Research And Molecular Biology, Vol 40 Xi+332p Academic Press, Inc : San Diego, California, Usa; London, England, Uk Illus 95-142
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Theall, G.; Low, K.B.; Soll, D. 1979: Regulation of the biosynthesis of aminoacyl transfer rna synthetases and of transfer rna in escherichia coli part 4 mutants with increased levels of leucyl transfer rna synthetase or seryl transfer rna synthetase Molecular and General Genetics 169(2): 205-212
Semenova, N.O.; Yel, S.K.A.V.; Matsuka, H.K. 1969: Specificity of interaction of transfer rna and aminoacyl transfer rna synthetase isolated from mammary gland tissue under various functional conditions Ukrayins'kyi Biokhimichnyi Zhurnal 41(3): 326-329
Kucherenko, N.E.; Vinogradova, R.P.; Tsudzevich, B.A.; Gavrelei, V.I. 1977: Modification by proserine and nicotinic acid of early post irradiation structural functional changes in transfer rna and aminoacyl transfer rna synthetase Radiobiologiya 17(1): 12-16
Webster, T.; Tsai, H.; Kula, M.; Mackie, G.A.; Schimmel, P. 1984: Specific sequence homology and three-dimensional structure of an aminoacyl transfer RNA synthetase Science 226(4680): 1315-1317
Webster, T.; Tsai, H.; Kula, M.; Mackie, G.A.; Schimmel, P. 1984: Specific sequence homology and 3 dimensional structure of an aminoacyl transfer rna synthetase Science 226(4680): 1315-1317
Pryme, I.F.; Berg, B.H. 1991: The activities of aminoacyl transfer rna synthetase phosphatase and aminoacyl transfer rna synthetases in mpc 11 and krebs ii ascites cells Cancer Letters 58(1-2): 119-124
Ludmerer, S.W.; Schimmel, P. 1987: Gene for yeast glutamine transfer rna synthetase encodes a large amino terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl transfer rna synthetases Journal of Biological Chemistry 262(22): 10801-10806