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Morphology and morphogenesis of the aujeszkys disease virus the mk 35 virus mutant and the virulent strain 2



Morphology and morphogenesis of the aujeszkys disease virus the mk 35 virus mutant and the virulent strain 2



Veterinarno Meditsinski Nauki 21(3): 9-19



Ultrastructural studies were carried out on the morphology and morphogenesis of the Aujeszky's disease avirulent immunogenic mutant strain MK 35 and the virulent parental strain 2. MK 35 had a delayed cycle of replication, lasting .apprx. 10 h when compared against the virulent strain 2. It also induced specific cytomorphology of infected cells as well as the synthesis of a predominantly virus antigen in the form of empty viral capsids with tubular shape. Culturing of the virulent strain in cell cultures in the presence of 5-bromodeoxyuridine led to the synthesis of a limited amount of mature viral particles. This process was observed 24 h after infection of the cell cultures.

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