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Multi variate biochemical indicators of breast cancer an evaluation of their potential in routine practice

Multi variate biochemical indicators of breast cancer an evaluation of their potential in routine practice

European Journal of Cancer 14(8): 885-894

A vertical study was made of the frequency of abnormalities of the levels of 3 tumor related antigens (CEA [carcinoembryonic antigen], .beta.HCG [.beta.-human chorionic gonadotropin] and casein), 2 serum enzymes (.gamma.-glutamyltranspeptidase and alkaline phosphatase), 4 acute phase reactant proteins (haptoglobin, acid glycoprotein, ceruloplasmin and antitrypsin) and a random study of C-Reactive protein in 429 women attending a breast clinic. While the frequency of abnormality increases with tumor load, these parameters seem unable to discriminate high risk groups in stages II and III from benign breast disease. The women are heterogenous with respect to their individual marker profiles. Elements within this panel of potential markers could be used to design a profile for longitudinal monitoring of recurrence in certain high risk groups, but as yet they do not appear to warrant their introduction into routine medical practice until they are proven to aid clinical decision making.

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Accession: 005941155

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PMID: 80319

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