+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Mutagenicity of anthracycline glycosides and bleomycins in Salmonella assay system



Mutagenicity of anthracycline glycosides and bleomycins in Salmonella assay system



Biomedicine and PharmacoTherapy 41(5): 214-218



Aclacinomycin A was nonmutagenic, while most anthracycline drugs such as daunomycin and adriamycin are highly mutagenic in a Salmonella test. But its derivative, N-demethylaclacinomycin A, was mutagenic. Similarly, aclavin, a hydrolysis product of aclacinomycin A, was nonmutagenic, but N-demethylaclavin was mutagenic. N-Methyldaunomycin showed only weak mutagenicity, and N-dimethyldaunomycin was nonmutagenic. Thus, the amino moiety of anthracycline glycosides is concluded to be essential for mutagenesis. Bleomycins were nonmutagenic to most Salmonella tester strains such as TA98, TA100 and TA92 and also to a Escherichia coli strain WP2/uvrA. Bleomycins were weakly mutagenic to Salmonella TA102 and TA94 strains which were extremely sensitive to detect DNA cross linking agents.

(PDF emailed within 1 workday: $29.90)

Accession: 005948271

Download citation: RISBibTeXText

PMID: 2444280


Related references

Mutagenicity of bleomycins phleomycins and talisomycins in salmonella typhimurium. Mutation Research 117(1-2): 9-20, 1983

Mutagenicity of bi-, tri- and tetra-cyclic aromatic hydrocarbons in the "taped-plate assay" and in the conventional salmonella mutagenicity assay. Mutation Research 204(2): 203-206, 1988

Mutagenicity of some congeners of benzidine in the Salmonella typhimurium assay system. Cancer Letters 4(1): 21-25, 1978

Mutagenicity of eight anthracycline derivatives in five strains of Salmonella typhimurium. European Journal of Cancer and Clinical Oncology 19(5): 641-647, 1983

Mutagenicity of 8 anthracycline derivatives in 5 strains of salmonella typhimurium. European Journal of Cancer & Clinical Oncology 19(5): 641-648, 1983

Effect of rifampicin induced S9 fraction on the mutagenicity of isoniazid in the Salmonella assay system. Indian Journal of Medical Research 86: 232-236, 1987

Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system. Biological & Pharmaceutical Bulletin 17(7): 990-992, 1994

Confidence limits for mutagenicity of weak mutagens in the ames salmonella mutagenicity assay. Environmental Mutagenesis 3(3): 367, 1981

Diverse mutagenicity of methylbenz[c]acridines in the direct Ames' Salmonella mutagenicity assay. Anticancer Research 16(5a): 2837-2841, 1996

The mutagenicity of metallized and unmetallized azo and formazan dyes in the salmonella mutagenicity assay. Environmental & Molecular Mutagenesis 41(3): 173, 2003

Mutagenicity studies of dioxin and related compounds with the Salmonella arabinose resistant assay system. Toxicity Assessment 3(2): 137-145, 1988

The mutagenicity of some proposed metabolites of a benzidine derived dye and a pigment in the salmonella typhimurium assay system. Environmental Mutagenesis 2(2): 309-310, 1980

Mutagenicity and toxicity studies of several alpha,beta-unsaturated aldehydes in the Salmonella typhimurium mutagenicity assay. Environmental Mutagenesis 9(3): 289-295, 1987