+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mutagenicity of beta oxidized n n di n propyl nitrosamine derivatives in salmonella typhimurium ta 1530 mediated by rat and hamster tissues



Mutagenicity of beta oxidized n n di n propyl nitrosamine derivatives in salmonella typhimurium ta 1530 mediated by rat and hamster tissues



Zeitschrift fuer Krebsforschung und Klinische Onkologie 86(3): 293-302



The relative abilities of liver, kidney and lung fractions from untreated or phenobarbitone pretreated rats and hamsters to convert N,N-di-n-propylnitrosamine and several .beta.-oxidized synthetic putative intermediates into mutagens was quantitatively compared in a tissue mediated mutagenicity assay with S. typhimurium TA1530 in vitro. With 1 exception, namely, N,N-di(2-acetoxy-n-propyl)nitrosamine, liver was the most active tissue from hamsters. In rats, only liver fractions were able to activate some nitroso compounds to mutagens. The highest enzyme-mediated mutagenicities were observed with N-2-hydroxy-n-propyl-N-n-propylnitrosamine, N,N-di-n-propylnitrosamine and N,N-di(2-acetoxy-n-propyl)nitrosamine. Hamster lung tissue converted N,N-di-n-propylnitrosamine, N-2-hydroxy-n-propyl-N-n-propylnitrosamine and N,N-di(2-acetoxy-n-propyl)nitrosamine into mutagens. Activity with the latter compound was greater with lung tissue than liver tissue when untreated animals were used. N-methyl-N-n-propylnitrosamine was mutagenic in the presence of hamster liver fraction but less so than N,N-di-n-propylnitrosamine. The results of the mutagenicity assays using various tissues are qualitatively compared to sites of tumor formation in rats and hamsters by these N-nitrosamines.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005948299

Download citation: RISBibTeXText


Related references

Mutagenicity of beta-oxidized N,N,-di-n-propylnitrosamine derivatives in S. typhimurium mediated by rat and hamster tissues. Zeitschrift für Krebsforschung und Klinische Onkologie. Cancer Research and Clinical Oncology 86(3): 293-302, 1976

Mutagenicity of -oxidized N,N-di-n-propylnitrosamine derivatives in s. typhimurium mediated by rat and hamster tissues. Journal of Cancer Research and Clinical Oncology 86(3): 293-302, 1976

The mutagenicity of di methyl nitrosamine di ethyl nitrosamine and nitroso morpholine in the host mediated assay with salmonella typhimurium strain g 46 and salmonella typhimurium strain ta 1950. Biologisches Zentralblatt 94(6): 661-669, 1975

The carcinogenic effect of beta oxidized di propyl nitrosamine in mice part 2 2 hydroxypropyl n propyl nitrosamine and 2 oxopropyl n propyl nitrosamine. Zeitschrift fuer Krebsforschung und Klinische Onkologie 91(2): 189-194, 1978

The carcinogenic effect of beta oxidized di propyl nitrosamine in mice part 1 di propyl nitrosamine and methylpropyl nitrosamine. Zeitschrift fuer Krebsforschung und Klinische Onkologie 90(3): 253-258, 1977

Mutagenicity testing of irradiated laboratory animal food in the host-mediated assay with Salmonella typhimurium TA 1530. Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 23(2): 117-121, 1976

Biphenyl and fluorinated derivatives: liver enzyme-mediated mutagenicity detected in Salmonella typhimurium and Chinese hamster V79 cells. Mutation Research 281(3): 151-156, 1992

Test of mutagenicity of an irradiated standard diet for laboratory animals in the host-mediated assay with Salmonella typhimurium TA 1530. Zentralblatt fur Veterinarmedizin: Reihe B: 23 (2) 117-121, 1976

Influence of microsomal and cytosolic fractions from rat mouse and hamster liver on the mutagenicity of di methyl nitrosamine in the salmonella typhimurium plate incorporation assay. Cancer Research 41(11 PART 1): 4361-4367, 1981

Early lesions during pancreatic carcinogenesis induced in the syrian hamster by di hydroxydi n propyl nitrosamine or di oxodi n propyl nitrosamine 2. ultrastructural findings. Carcinogenesis 4(4): 439-448, 1983

Early lesions during pancreatic carcinogenesis induced in syrian hamster by di hydroxydi n propyl nitrosamine or di oxo di n propyl nitrosamine 1. histologic histochemical and radioautographic findings. Carcinogenesis 4(4): 431-438, 1983

Deacetylase mediated mutagenicity of n hydroxy 4 acetylamino biphenyl n oh aabp by urothelial tissues in salmonella typhimurium ta98nr. Federation Proceedings 46(4): 1134, 1987

Mutagenic activities of oxidized derivatives of N-nitrosodipropylamine in the liver cell-mediated and Salmonella typhimurium assays. Cancer Research 40(10): 3463-3467, 1980

Mutagenicity in salmonella typhimurium of n 3 methylbutyl n 1 methylacetonyl nitrosamine and n methyl n benzyl nitrosamine n nitrosation products isolated from corn bread contaminated with commonly occurring molds in linshien county a high incidence area for esophageal cancer in northern china. Carcinogenesis 1(10): 867-870, 1980

Evaluation of propanil and its n oxidized derivatives for genotoxicity in the salmonella typhimurium reversion chinese hamster ovary hypoxanthine guanine phosphoribosyltransferase and rat hepatocyte dna repair assays. Fundamental & Applied Toxicology 11(3): 429-439, 1988