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Mutagenicity tests with gallic acid and tannic acid in the salmonella typhimurium mammalian microsome assay



Mutagenicity tests with gallic acid and tannic acid in the salmonella typhimurium mammalian microsome assay



Journal of Environmental Science & Health Part B Pesticides Food Contaminants & Agricultural Wastes 20(2): 153-166



Gallic acid, tannic acid mixture and a purified fraction of tannic acid were evaluated for possible mutagenic activity in 3 strains of S. typhimurium, TA98, TA100 and TA1535. These chemicals were not mutagenic either before or after activation with rat and woodchuck microsomal and cytosolic enzymes. However, tannic acid mixture and tannic acid fraction both gave a significantly (P = 0.05) dose-related reduction in the number of the revertant colonies, compared to the normal spontaneous revertants with no apparent toxic effects in the background lawn. With an agar diffusion assay, the chemicals exhibited toxic effects at 5000 .mu.g/disc.

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Accession: 005948793

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