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Myasthenia in patients with dermato myositis clinical electro physiological and ultrastructural studies


, : Myasthenia in patients with dermato myositis clinical electro physiological and ultrastructural studies. Journal of the Neurological Sciences 38(2): 129-144

In 4 patients with clinical signs of dermatomyositis, confirmed by electromyography and muscle biopsy, a form of muscle fatigue was detected which was expressed clinically by predominantly proximal motor deficit, wity phonation and deglutition disturbances, slightly influenced by prostigmine. In all patients, stimulation of the ulnar nerve at 3-10 Hz induced a decrement of muscle-evoked potentials in abductor digiti minimi and at 15-50 Hz and increment at the end of the trains (1.2 s in duration) of repetitive stimulation (preceded in 2 cases by a decrement in the response to the 5th stimulus in the train). Stimulation at 30 Hz for 10 s resulted in a transient facilitaiton, followed (at 3 Hz stimulation) by postactivation exhaustion which disappeared after 5-15 min. The post-tetanic facilitation, the incremental response and the myasthenic symptoms reverted to normal under treatment with corticosteroids, an immunosuppressor agent and guanidine hydrochloride. A mixed, pre- and postsynaptic mechanism may underlie the muscle fatigue in these patients. EM of muscle biopsies disclosed zones of necrosis and, in incipient stages, large agglomerations of glycogen that disorganized the structure of myofibrils. The end-plates in the biopsies were larger than normal and the cholinesterase reaction was hyperactive. Serum immunoelectrophoretic and electrophoretic data.sbd.increase of Ig[immunoglobulin]G and IgM, decrease of IgA and hypergammaglobulinemia.sbd.point to a possible autoimmune mechanism of the neuromuscular disorders in these patients.

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Pickering R.J., 1968: Significance of abnormalities of serum complement in human disease complement component 2 deficiency hypo gamma globulinemia syndrome hereditary angio neurotic edema. Postgraduate Medicine 43(6): 39-43

Duerr W.; Ingwersen H.; Krause N.; Oppelt R., 1989: Truncated cone shaped surface resonator for nmr tomography us patent 4841249 june 20 1989. Official Gazette of the United States Patent & Trademark Office Patents 1103(3): 1910

Masuoka, Howard C.; Rosen, Charles B., 2011: Liver Transplantation for Hepatocellular Carcinoma Expanding Frontiers and Building Bridges. Despite significant advances in nonsurgical treatments of hepatocellular carcinoma, these approaches rarely result in cure. Surgery remains the mainstay of curative therapy for hepatocellular carcinoma. Liver transplantation, in particular, has em...

Deane, Colin, R.; Markus, Hugh, S., 1997: Colour velocity flow measurement: In vitro validation and application to human carotid arteries. Ultrasound measurement of volume blood flow is potentially useful for many clinical situations, yet practical implementation and use are restricted by the many instrumentation and blood flow limitations that can arise. Colour velocity imaging offe...

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Smith L., 1970: A new instrument for measuring rib movement. Journal Of Applied Physiology: 501-504

Anonymous, 2012: Benign lymphoepithelial tumor of the pituitary. Here, we report a case of lymphoepithelial tumor that developed in the sellar and suprasellar regions in a 56-year-old woman. The lesion was composed of abundant but benign squamous cell nests (Erdheim's nests) and heavy lymphoid tissue with...

Terabayashi, S., 1978: Studies in the morphology and systematics of berberidaceae part 2 floral anatomy of mahonia japonica and berberis thunbergii. Anatomical observations were made of the flowers of M. japonica and B. thunbergii with special reference to the floral vasculature. In regard to the floral vasculature, the 2 spp. exhibit the same fundamental plan. In both species, the floral elem...

Nikolaev, Andrey, R.; Ziessler, Michael; Dimova, Kamelia; Van-Leeuwen, Cees, 2008: Anticipated action consequences as a nexus between action and perception Evidence from event-related potentials. We used high-density event-related potentials (ERP) in a modified flanker paradigm to study the role of anticipated action consequences in action planning and the role of anticipation in the perception of action consequences. Prior to the experim...

Vanderhoeden R.; Bremer A.; Parmentier R., 1969: Regional enteritis of the duodenal bulb and the terminal ileum. Bruxelles Medical 49(5): 356