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Naloxone can alter experimental pain and mood in humans

Naloxone can alter experimental pain and mood in humans

Physiological Psychology 9(3): 245-250

The possibility was studied that endogenous opioids attenuate aversive experience in humans. Two experimental pain procedures, cold pressor pain, and ischemic pain produced by the submaximal effort tourniquet technique, were administered on each of 2 consecutive experimental days. Seven subjects received double-blind infusions of the opiate antagonist naloxone on day 1 and saline on day 2; for 7 other subjects, the order was reversed. Based on earlier studies of exogenous opiate analgesics, the present experiment was designed to maximize subject anxiety and the disturbingness of the ischemic pain. Under these conditions, opiate receptor blockade significantly affected ratings and tolerance times for ischemic pain, anxiety and mood. These results contrast with those of recent studies in which naloxone effects on experimental pain in humans were subtle or indiscernible, and suggest that psychological factors will have to be controlled and studied in the investigation of physiological bases of pain and other psychological states.

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Accession: 005956273

Download citation: RISBibTeXText

DOI: 10.3758/BF03326970

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