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Naloxone fails to reverse hypnotic alleviation of chronic pain

Naloxone fails to reverse hypnotic alleviation of chronic pain

Psychopharmacology 81(2): 140-143

The hypothesis that the alleviation of chronic pain with hypnosis is mediated by endorphins was tested. Six patients with chronic pain secondary to peripheral nerve irritation were taught to control the pain using self-hypnosis. Each subject was tested at 5-min intervals during four 1-h sessions for the amount of pain reduction sensation and suffering associated with hypnosis while being given, in a random double-blind crossover fashion either 10 mg naloxone or a saline placebo i.v. through an indwelling catheter. The patients showed significant alleviation of the pain with hypnosis, but this effect was not significantly diminished in the naloxone condition. Evidently, endorphins are not involved in hypnotic analgesia.

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Accession: 005956344

Download citation: RISBibTeXText

PMID: 6415744

DOI: 10.1007/bf00429008

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