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Natural and experimental infection of the marmot marmota marmota by the woodchuck hepatitis virus marmota monax



Natural and experimental infection of the marmot marmota marmota by the woodchuck hepatitis virus marmota monax



Comparative Immunology Microbiology & Infectious Diseases 7(3-4): 179-194



The natural infection of M. monax by the woodchuck hepatitis virus (WHV) shows that the woodchuck is a good model for human B hepatitis and should be extended to the marmot M. marmota. A sample of 24 marmots caught in the Alpes of Haute-Province has not revealed any spontaneous infection in these animals by the woodchuck virus. The failure of experimental inoculation of the marmot (24 animals) with the WHV confirms the refractory status of this species (no viremia and very low and short serological response with or without an immunosuppressive treatment). These preliminary results require a conformation in the other animals of different age and geographical region and also by using more specific tests such as molecular hybridation, research on DNA polymerase and direct transfection trials.

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