Natural killer (NK) cell activity of peripheral blood, synovial fluid, and synovial tissue lymphocytes from patients with rheumatoid arthritis and juvenile rheumatoid arthritis

Dobloug, J.H.; Førre, O.; Kvien, T.K.; Egeland, T.; Degré, M.

Annals of the Rheumatic Diseases 41(5): 490-494

1982


ISSN/ISBN: 0003-4967
PMID: 6181746
DOI: 10.1136/ard.41.5.490
Accession: 005958974

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Abstract
Natural killer (NK) cell activity was investigated in peripheral blood, synovial fluid, and synovial tissue lymphocytes from patients with rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA). Unfractionated lymphocytes, T lymphocytes and non-T lymphocytes from the 3 compartments of JRA patients had reduced activity compared with that of normal peripheral blood lymphocytes (with P values usually between 0.05-0.1). Unfractionated synovial tissue lymphocytes of RA patients also showed reduced cytotoxicity (0.05 < P < 0.1), whereas peripheral blood lymphocytes exerted normal NK cell activity. The NK activity was exerted by cells both with and without Fc.gamma. receptors. The highest cytotoxicity was observed in Fc.gamma. receptor-positive cells, both in peripheral blood and synovial fluid, since more than 70% reduction in NK activity was found after depletion of Fc.gamma. receptor-positive cells. No evidence of lymphocytotoxic antibodies or other factors with influence on NK cells was observed in the patients' sera.