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Natural killer cyto toxicity of human lymphocytes in vitro 2. cyto toxicity enhanced by bcg phyto hem agglutinin pokeweed mitogen purified protein derivative and streptococcus pyogenes lipo poly saccharide against a human skin cancer cell line



Natural killer cyto toxicity of human lymphocytes in vitro 2. cyto toxicity enhanced by bcg phyto hem agglutinin pokeweed mitogen purified protein derivative and streptococcus pyogenes lipo poly saccharide against a human skin cancer cell line



Journal of Dermatology (Tokyo) 10(5): 469-474



BCG, PHA [phytohemagglutinin], PWM [pokeweed mitogen], PPD [purified protein derivative] and LPS-Su [Streptococcus pyrogenes lipopolysaccharide] all enhanced the natural killer-like cytotoxicity of the nylon wool-treated human lymphocyte fraction against a human skin squamous cell line (HSC-1) in vitro. The cytotoxicity was measured by 51Cr release from the target cells (HSC-1) when they were mixed with lymphocytes preincubated with or without the stimulators for 3 days. The activity of BCG and PPD in enhancing the lymphocyte cytotoxicity was stable after sonication and heating, although it was slightly lowered after treatment of BCG with streptomycin. The [human leukemia] K-562 cell line, which apparently was specifically sensitive to the natural killer activity, proved to be also sensitive to the cytotoxic effect of the nylon wool-treated lymphocyte fraction enhanced by BCG and PHA as well as OK-432.

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Accession: 005959082

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