Nature of thymus derived cells resident in spleens of thymectomized lethally irradiated bone marrow reconstituted mice

Sado, T.; Kamisaku, H.; Aizawa, S.

Cellular Immunology 49(1): 51-63


ISSN/ISBN: 0008-8749
Accession: 005960590

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Adult thymectomized, lethally irradiated, bone marrow-reconstituted (ATxXB) mice that had been weakly primed with SRBC A, in vitro. Treatment of donor bone marrow cells used for reconstitution of ATxXB mice with anti-Thy 1.2 sera + C' did not affect generation of immunological memories nor the magnitude of the proliferative response of spleen cells to nonspecific T cell mitogens in vitro, indicating that cells responsible for such functions were host derived. The antibody-forming capacity of spleen cells derived from SRBC-primed ATxXB mice to the test antigen in vitro was completely abrogated by exposure to 450 R, whereas the helper function of the same cell suspension remained unaffected even after exposure to 1000 R. Implication of these findings on the nature of T cells resident in spleens of ATxXB mice was discussed.