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Neolignans from piper hancei



Neolignans from piper hancei



Yaoxue Xuebao 21(5): 361-365



Piper hancei Maxim, Family Piperaceae, has been used in Chinese folk medicine for the treatment of rheumatoid arthritis and asthma. A new neolignan, hancinone (III) was isolated together with two known neolignans, kadsurenone (I) and denudatin B (II). The structure of hancinone (III) was established as (7S, 8R, 3'S)-1'-allyl-3'-methoxy-7-(3,4-methylenedioxyphenyl)-8-methyl-7,8,3',6'-tetrahydro-6'-oxobenzofuran through interpretation of the spectral data (UV, IR, NMR and MS) and the results of a single crystal X-ray analysis. Kadsurenone (I) and denudatin B (II) were isolated for the first time from this plant. In the PAF receptor binding assay and the test of platelet aggregation, denudatin B (II) was substantially less active than kadsurenone (I), whereas hancinone (III) showed no PAF antagonistic activity.

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Accession: 005963481

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PMID: 3776545


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