Nerve growth factor induced turnover of phosphatidylinositol in rat superior cervical ganglia

Lakshmanan, J.

Biochemical and Biophysical Research Communications 82(3): 767-775


ISSN/ISBN: 0006-291X
PMID: 697771
DOI: 10.1016/0006-291x(78)90848-3
Accession: 005965151

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The addition of nerve growth factor to organ cultures of superior cervical ganglia from immature rats specifically stimulated the incorporation of 32P-orthophosphate into phosphatidylinositol fraction. Equimolar concentrations of other hormones such as insulin, glucagon, thyroxine and growth hormone did not cause any stimulation of the incorporation of 14C-myoinositol into phosphatidylinositol. The stimulation of phosphatidylinositol turnover was observed over a concentration of nerve growth factor ranging from 10-10 M-10-7 M. Nerve growth factor specific inositide effect was sensitive to nerve growth factor antibody, 2,4-di-nitrophenol, a high concentration of bovine growth hormones but not to actinomycin D. The physiological significance of this finding in relation to nerve growth factor action in this target tissue is discussed.