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Netilmicin in human cerebro spinal fluid after parenteral administration in patients with slightly and severely impaired blood cerebro spinal fluid barrier



Netilmicin in human cerebro spinal fluid after parenteral administration in patients with slightly and severely impaired blood cerebro spinal fluid barrier



Journal of Antimicrobial ChemoTherapy 11(6): 565-572



After administration of 150 mg of the antibacterial drug netilmicin, CSF and blood samples were obtained. In 1 group of 9 patients with no or only slight impairment of the blood-CSF barrier, 29 samples of CSF were assayed for netilmicin concentrations. All samples obtained after the 1st dose failed to reveal detectable drug levels. Drug levels up to 0.18 mg/l were detected in samples of CSF of 3 patients after 3-22 doses. Only the lumbar CSF of 1 patient contained netilmicin concentrations > 1.0 mg/l; 19 CSF samples, obtained from patients with meningitis after > 1 dose of netilmicin, had levels of 0.27-5.0 mg/l. Three CSF samples from patients out of this group, collected after the 1st dose of netilmicin, failed to show any drug activity.

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