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New cell surface gp 70 related to friend mink cell focus inducing virus is expressed on friend virus induced erythro leukemic spleen cells after elimination of ecotropic friend virus gp 70 in rfv 3r s mice



New cell surface gp 70 related to friend mink cell focus inducing virus is expressed on friend virus induced erythro leukemic spleen cells after elimination of ecotropic friend virus gp 70 in rfv 3r s mice



Journal of Experimental Medicine 154(3): 868-882



Spleen cells from Rfv/3r/s mice with Friend virus-induced erythroleukemia were analyzed for expression of viris-induced proteins with monoclonal antiviral antibodies and conventional antisera. Leukemic spleen cells, 30-60 days after virus inoculation, expressed decreased amounts of ecotropic Friend murine leukemia helper virus gag- and env-encoded cell surface and intracellular proteins compared with leukemic cells tested 8-10 days after virus inoculation. The spleen focus-forming virus-induced protein, gp55, was present on both leukemia cell populations. This difference appeared to be mediated by the humoral antibody response in Rfv-3r/s mice, which could recognize only ecotropic gag and env proteins, not gp55. A new gp70 molecule cross-reactive with a recombinant Friend mink cell focus-inducing virus was found in large quantities on late leukemic cells. This protein appeared to be derived from a recombinant virus produced during the course of Friend virus infection. The appearance of this new gp70 suggests that recombinant viruses other than spleen focus-forming virus may play a role in Friend virus-induced erythroleukemia.

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Accession: 005974677

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PMID: 6974219


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New cell surface gp70 related to Friend mink cell focus-inducing virus is expressed on Friend virus-induced erythroleukemic spleen cells after elimination of ecotropic Friend virus gp70 in Rfv-3r/s mice. Journal of Experimental Medicine 154(3): 868-882, 1981

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