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New evidence for glutamic acid as an iron ligand in hem erythrin

New evidence for glutamic acid as an iron ligand in hem erythrin

Biochemical and Biophysical Research Communications 85(4): 1360-1366

The amino acid sequence of the respiratory protein, hemerythrin, from Phascolopsis gouldii was reinvestigated in the region of residue 58. Sequenator analyses were performed on peptide 50-113, obtained by trypsin digestion of the intact protein, and on peptide 50-62, obtained by cyanogen bromide cleavage of peptide 50-113. In both peptides residue 58 was unambiguously identified as glutamic acid and residue 59 as glutamine. This corrects a previous mistake in the assignment of residue 58 and makes its proposed role as an iron ligand more plausible.

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Accession: 005976355

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PMID: 743303

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