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Nifedipine reduces adenine nucleotide breakdown in ischemic rat heart



Nifedipine reduces adenine nucleotide breakdown in ischemic rat heart



European Journal of Pharmacology 81(1): 89-96



An ATP-sparing effect has been demonstrated for a number of Ca antagonists. Nifedipine may have a similar action. The effect of nifedipine on high-energy phosphate (and carbohydrate) metabolism was studied in the ischemic rat heart. Langendorff preparations were made ischemic for < 15 min. The reduction in coronary flow was 60 or 70%. Apex displacement during ischemia, a measure of contractility, was comparable for nifedipine-treated and untreated hearts. Ischemia caused a considerable release of the AMP catabolites adenosine, inosine and (hypo)xanthine and of lactate. Nifedipine (10-100 .mu.g/l) prevented this in a dose-dependent way. The highest dose reduced the release of purines and lactate by 90% (P < 0.01) and 60% (P < 0.001), respectively. The drug acted in a similar way during reperfusion. Due to ischemia, the adenylate energy charge (ATP + 0.5 ADP)/(ATP + ADP + AMP) decreased 15% (P < 0.001); nifedipine 100 .mu.g/l prevented this decrease (P < 0.05). Evidently, nifedipine exerts a beneficial effect on myocardial adenine nucleotide metabolism during ischemia and reperfusion.

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Accession: 005984136

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PMID: 7117372

DOI: 10.1016/0014-2999(82)90604-5


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