Nocturnal inhibition of lipolysis in man by nicotinic acid and derivatives

Kruse, W.; Kruse, W.; Raetzer, H.; Heuck, C.C.; Oster, P.; Schellenberg, B.; Schlierf, G.

European Journal of Clinical Pharmacology 16(1): 11-15

1979


ISSN/ISBN: 0031-6970
PMID: 499296
DOI: 10.1007/bf00644960
Accession: 005989362

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Abstract
The effect of nicotinic acid and several derivatives on the nocturnal level of free fatty acids [FFA] was studied in 12 healthy young women and men. FFA are an important precursor of plasma triglycerides and their concentration is highest at night. The drugs used were nicotinic acid, .beta.-pyridyl-carbinol, mesoinositol hexanicotinate and xantinol nicotinate. The highest plasma nicotinic acid level was seen with .beta.-pyridyl-carbinol, but significant reduction in free fatty acids during the entire night was achieved with inositol hexanicotinate and xantinol nicotinate. There was no correlation between the plasma levels of FFA and nicotinic acid at any sampling time. If prolonged reduction in FFA concentration is desired in the therapy of hyperlipidemias, the inositol and xantinol esters of nicotinic acid appear to be superior to the other preparations.

Nocturnal inhibition of lipolysis in man by nicotinic acid and derivatives